Media

Three Questions

Events

Creatine Conference 2022

The International Conference on „Creatine in Health and Disease throughout Lifetime“ brought together the world’s most eminent creatine researchers (unfortunately only in virtual format) to accelerate the awareness about the role of creatine supplementation for health and clinical diseases. Experts in healthcare, exercise, nutrition, as well as wellness professionals, young researchers, business delegates and students from all over the world were invited to participate.

A Conference Book of 265 pages, published as Special Issue “Creatine Supplementation for Health and Clinical Diseases“ was published in „Nutrients“. The book, edited by Dr. Richard B. Kreider and Dr. Jeffrey R. Stout, is available online and individual lectures can be followed on Youtube.

Factsheet Crearene

Crearene, University Medical Center of Groningen and Alzchem announce further details on results of clinical study administrating creatine during hemodialysis
Bidiphar and Crearene agree to work on Innovative Treatments for the Dialysis Market
Feasibility-, safety- and dose finding study
Klinische Studie
Clinical Study
Neue Positionsverteilungen im Verwaltungsrat der Crearene AG
Neuwahl von Verwaltungsrat und Geschäftsleitung
Beiratsberufungen für die Crearene AG
Alzchem und Crearene erschließen den Gesundheitsmarkt Dialyse
Alzchem and Crearene Develop Treatments for the Dialysis Market

Zhou B, Hong M, Jin L, Ling K.
Exploring the relationship between creatine supplementation and renal function: insights from Mendelian randomization analysis.
Ren Fail. 2024 Dec;46(2):2364762. doi: 10.1080/0886022X.2024.2364762. Epub 2024 Jun 14. https://www.tandfonline.com/doi/full/10.1080/0886022X.2024.2364762

Post A, Groothof D, Kremer D, Knobbe TJ, Abma W, Koops CA, Tsikas D, Wallimann T, Dullaart RPF, Franssen CFM, Kema IP, Heiner-Fokkema MR, Bakker SJL.
Creatine homeostasis and the kidney: comparison between kidney transplant recipients and healthy controls.
Amino Acids. 2024 Jun 13;56(1):42. doi: 10.1007/s00726-024-03401-w. https://link.springer.com/article/10.1007/s00726-024-03401-w

Post A, Garcia E, Shalaurova I, Matyus SP, González-Delgado JM, Doorenbos CSE, van der Veen Y, Shah SH, Kraus WE, Kremer D, Knobbe TJ, Bakker SJL, Dullaart RPF, Connelly MA.
Creatine and creatinine quantified using nuclear magnetic resonance: A method validation study and clinical associations between circulating creatine and fatigue in kidney transplant recipients.
Clin Chim Acta. 2023 Aug 1;548:117517. doi: 10.1016/j.cca.2023.117517. https://www.sciencedirect.com/science/article/pii/S0009898123003194?via%3Dihub

Igor Longobardi, Bruno Gualano, Antonio Carlos Seguro and Hamilton Roschel.
Is It Time for a Requiem for Creatine Supplementation-Induced Kidney Failure? A Narrative Review
Nutrients (2023), 15, 1466. https://doi.org/10.3390/nu15061466

Post A, Kremer D, Swarte JC, Sokooti S, Vogelpohl FA, Groothof D, Kema IP, Garcia E, Connelly MA, Wallimann T, Dullaart RPF, Franssen CFM, Bakker SJL.
Plasma creatine concentration is associated with incident hypertension in a cohort enriched for the presence of high urinary albumin concentration: the Prevention of Renal and Vascular Endstage Disease study.
J Hypertens. 2022 Feb 1;40(2):229-239. doi: 10.1097/HJH.0000000000002996. https://journals.lww.com/jhypertension/fulltext/2022/02000/plasma_creatine_concentration_is_associated_with.5.aspx

Yvonne van der Veen, Adrian Post, Daan Kremer, Christa A. Koops, Erik Marsman, Theo Y. Jerôme Appeldoorn, Daan J. Touw, RalfWesterhuis, Margaretha Rebecca Heiner-Fokkema, Casper F. M. Franssen, Theo Wallimann and Stephan J. L. Bakker.
Chronic Dialysis Patients Are Depleted of Creatine: Review and Rationale for Intradialytic Creatine Supplementation.
Nutrients (2021) 13: 2709-2723. DOI: 10.3390/nu13082709

https://www.mdpi.com/2072-6643/13/8/2709/htm

Adrian Post , Joëlle C. Schutten, Daan Kremer, Yvonne van der Veen, Dion Groothof, Camilo G. Sotomayor, Christa A. Koops, Pim de Blaauw, Ido P. Kema, Ralf Westerhuis, Theo Wallimann, M. Rebecca Heiner‑Fokkema, Stephan J. L. Bakker and Casper F. M. Franssen.
Creatine homeostasis and protein energy wasting in hemodialysis patients.
J. Translational Medicine (2021) 19(1):115-130. DOI: 10.1186/s12967-021-02780-y

Marini ACB, Motobu RD, Freitas ATV, Mota JF, Wall BT, Pichard C, Laviano A, Pimentel GD.
Short-Term Creatine Supplementation May Alleviate the Malnutrition-Inflammation Score and Lean Body Mass Loss in Hemodialysis Patients: A Pilot Randomized Placebo-Controlled Trial.
JPEN J Parenter Enteral Nutr. 2020 Jul;44(5):815-822. doi: 10.1002/jpen.1707. Epub 2019 Sep 18. PMID: 31531996 https://aspenjournals.onlinelibrary.wiley.com/doi/10.1002/jpen.1707

Adrian Post, Dimitrios Tsikas, Stephan J.L. Bakker.
Creatine is a Conditionally Essential Nutrient in Chronic Kidney Disease: A Hypothesis and Narrative Literature Review.
Nutrients (2019) 11(5):1044-1058. DOI: 10.3390/nu11051044

Theo Wallimann, Uwe Riek, Michael Möddel.
Intradialytic creatine supplementation: A scientific rationale for improving the health and quality of life of dialysis patients
Medical Hypotheses (2017) 99:1-14. DOI: 10.1016/j.mehy.2016.12.002

Theo Wallimann, Michael Möddel.
Kreatin-Supplementation und Nierenfunktion: Reines Kreatin ist nicht schädlich für die Nieren!
Swiss Medical Forum (SMF) (2013) 13(4): 848-850.

Hui Li, Ramon F Thali, Christy Smolak, Fan Gong, Rodrigo Alzamora, Theo Wallimann, Roland Scholz, Núria M Pastor-Soler, Dietbert Neumann, Kenneth R Hallows.
Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells.
Am J Physiol Renal Physiol (2010) 299(1): F167-F177. DOI: 10.1152/ajprenal.00162.2010

Theo Wallimann and Wolfram Hemmer.
Creatine kinase in non-muscle tissues and cells.
Mol Cell Biochem (1994) 133-134: 193-220. DOI: 10.1007/BF01267955

Wallimann T, Tokarska-Schlattner M, Schlattner U.
The creatine kinase system and pleiotropic effects of creatine.
Amino Acids. 2011 May;40(5):1271-96. doi: 10.1007/s00726-011-0877-3.
https://link.springer.com/article/10.1007/s00726-011-0877-3

Creatine Supplementation for Health and Clinical Diseases
Special Volume for the virtual Creatine Conference, March 16-19 2022
Richard B. Kreider adn Jeffrey R. Stout (EDITORS) USA
SBN 978-3-0365-2155-8 (Hbk); ISBN 978-3-0365-2156-5 (PDF)
https://doi.org/10.3390/books978-3-0365-2156-5 (registering DOI)
free download https://doi.org/10.3390/nu14061230

Ostojic, S.M.
Low Tissue Creatine: A Therapeutic Target in Clinical Nutrition.
Nutritions 2022, 14, 1230. https://doi.org/10.3390/nu14061230

Jose Antonio , Darren G. Candow, Scott C. Forbes, Bruno Gualano, Andrew R. Jagim, Richard B. Kreider, Eric S. Rawson, Abbie E. Smith-Ryan, Trisha A. VanDusseldorp, Darryn S. Willoughby and Tim N. Ziegenfuss
Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?
Journal of the International Society of Sports Nutrition (2021) 18:13. DOI: 10.1186/s12970-021-00412-w

Special Issue on: “Creatine Supplementation for Health and Clinical Diseases”
(with more than 20 expert publications on the state of the art of Creatine Supplementation)
(edited by Richard B. Kreider and Jeffrey R. Stout). Nutrients (2021) (in press).

Richard B. Kreider and Jeffrey R. Stout.
Creatine in Health and Disease.
Nutrients (2021) 13(2): 447-474. DOI: 10.3390/nu13020447

Theo Wallimann, Caroline H T Hall, Sean P Colgan, Louise E Glover.
Creatine Supplementation for Patients with Inflammatory Bowel Diseases:
A Scientific Rationale for a Clinical Trial.
Nutrients (2021) 13: 1429-1443. DOI: 10.3390/nu13051429

Emre Turer, William McAlpine, Kuan-wen Wang, Tianshi Lu, Xiaohong Li, Miao Tang, Xiaoming Zhan, Tao Wang, Xiaowei Zhan, Chun-Hui Bu, Anne R. Murray, and Bruce Beutler.
Creatine maintains intestinal homeostasis and protects against colitis.
Proc Natl Acad Sci U S A (2017) 114(7):E1273-E1281. DOI: 10.1073/pnas.1621400114

Richard B. Kreider, Douglas S. Kalman, Jose Antonio, Tim N. Ziegenfuss, Robert Wildman, Rick Collins, Darren G. Candow, Susan M. Kleiner, Anthony L. Almada and Hector L. Lopez.
International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine.
Journal of the International Society of Sports Nutrition (2017) 14:18-36. DOI: 10.1186/s12970-017-0173-z

Douglas G. Kondo, Lauren N. Forrest, Xianfeng Shi, Young‑Hoon Sung, Tracy L. Hellem, Rebekah S. Huber, Perry F. Renshaw.
Creatine target engagement with brain bioenergetics: a dose‑ranging phosphorus‑31 magnetic resonance spectroscopy study of adolescent females with SSRI‑resistant depression.
Amino Acids (2016) 48(8):1941-1954. DOI: 10.1007/s00726-016-2194-3

Special Issue on: “Creatine for Life: in Health, Sport and Medicine”
(with 26 expert publications on the state of the art of Creatine Kinase & Creatine Supplementation)
(edited by Theo Wallimann and Roger Harris). Amino Acids (2016) Volume 48(8): 1438-2199.

Theo Wallimann, Roger Harris.
Creatine: a miserable life without it.
Amino Acids (2016) 48:1739-1750. DOI: 10.1007/s00726-016-2297-x

R Guzun, T Kaambre, R Bagur, A Grichine, Y Usson, M Varikmaa, T Anmann, K Tepp,
N Timohhina, I Shevchuk, V Chekulayev, F Boucher, P Dos Santos, U Schlattner, T Wallimann, A V Kuznetsov, P Dzeja, M Aliev, V Saks.
Modular organization of cardiac energy metabolism:energy conversion, transfer and feedback regulation.
Acta Physiologica (Oxford, England) (2015) 213(1): 84-106. DOI: 10.1111/apha.12287

Malgorzata Tokarska-Schlattner, Raquel F. Epand, Flurina Meiler, Giorgia Zandomeneghi, Dietbert Neumann, Hans R. Widmer, Beat H. Meier, Richard M. Epand, Valdur Saks, Theo Wallimann, Uwe Schlattner.
Phosphocreatine Interacts with Phospholipids, Affects Membrane Properties and Exerts Membrane-Protective Effects.
PLoS One (2012) 7(8): e43178. DOI: 10.1371/journal.pone.0043178

Theo Wallimann (2008)
Mehr Energie – mehr Leistung. Kreatin – warum, wann und für wen?
Schweizer Zeitschrift für Ernährungsmedizin (2008) 5: 29-39.

Wyss M, Kaddurah-Daouk R.
Creatine and creatinine metabolism.
Physiol Rev. (2000) 80(3):1107-213. DOI: 10.1152/physrev.2000.80.3.1107

Wallimann T, Wyss M, Brdiczka D, Nicolay K, Eppenberger HM
Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the “Phospho-Creatine Circuit” for cellular energy homeostasis.
Biochem J. (1992) 281(1):21-40. DOI: 10.1042/bj2810021